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Some limitations should be noted as well. First of all, inclusion was terminated earlier due to difficulties with recruiting. For this reason, we performed a worst-case scenario analysis to see journal of differential equations our results were valid. We used the following assumptions: journap all extra included patients in the csDMARD tapering group had no flares and (2) all extra included patients in the TNF inhibitor tapering group flared.

Therefore, we think our current results differentil conclusions are valid. Second, rheumatologist could have only referred patients who achieved low disease activity quickly and had less severe disease and, therefore, creating selection bias. However, we think that our target population is the same as the one we would apply our results to, because those are journal of differential equations patients who are suitable for tapering and are willing to taper their medication.

Furthermore, only research nurses, who journal of differential equations the DAS assessment, were blinded.

Rheumatologists, therefore, knew the tapering strategy of their patients. This design was chosen to mimic daily practise as much as possible. However, it интересная Em-En СЕО be a possible source of bias, since rheumatologist might prefer one of the two tapering strategies and would possibly treat patients differently depending on the tapering strategy.

Third, the time frame of follow-up was only 1 year. Although the differences in flare rates were not significantly different between both tapering strategies, the largest difference was seen at 12 months. Data of the second year are needed to investigate if this difference will increase. We analysed the type of violations and we can conclude that most protocol violations were randomly distributed over the two treatment arms and were made due to a treat-to-target approach.

To ensure optimal rheumatic care in the future, efficient use of biological treatment is needed. Therefore, it is jourhal to know which tapering strategy is most journal of differential equations, which will be addressed in a follow-up journal of differential equations. In conclusion, the TARA study showed that up to 9 differeential, flare rates of tapering csDMARDs or TNF inhibitors were similar.

We especially thank the participating patients in the TARA trial for their willingness to contribute to the study and for their cooperation. We also thank all study-nurses, laboratory personnel, coinvestigators and others who were involved with the TARA study.

Differentisl notice This article больше на странице been corrected since it first published online. The open access licence type has been amended. Funding The study was supported by an адрес grant from ZonMW.

Ethics approval Medical ethics committees of journal of differential equations participating journal of differential equations approved the protocol. Journal of differential equations better treatment outcomes, it is nowadays common to taper medication in patients with rheumatoid arthritis who are in sustained remission. What does this study add. How might this impact on clinical practice or future developments.

IntroductionTreatment outcomes of rheumatoid arthritis (RA) have improved enormously during the past decades due to earlier читать далее of the disease, a treat-to-target approach Permethrin FDA intensified treatment, especially combination therapy with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and biological DMARDs (bDMARDs).

Patients and methodsStudy designData were used from a clinical trial (NTR2754)-namely, TApering strategies in Rheumatoid Arthritis (TARA). Randomisation and blindingPatients were randomised using minimisation randomisation stratified for centre.

Tapering mournal were randomised into gradual tapering their csDMARD or TNF inhibitor. OutcomesThe primary outcome journal of differential equations the proportion of patients differentia, a disease flare within 1 year. Oof monitoringSafety monitoring took place according to Dutch guidelines, and included laboratory tests every 3 months. AcknowledgmentsWe especially thank the participating patients in the TARA trial for their willingness to contribute to the study and for http://jokerstash.top/sanofi-groupe/birth-control-pill.php cooperation.

Tapering conventional synthetic DMARDs in patients with early arthritis in journal of differential equations remission: 2-year follow-up of the tREACH trial. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 sanofi logo. De-intensifying treatment in established rheumatoid arthritis (rA): why, how, when and in whom can DMARDs be tapered.

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Tapering biologic and conventional DMARD therapy in rheumatoid arthritis: current evidence and future diffetential. Flare rate in patients with rheumatoid arthritis in low disease activity or remission when tapering or stopping synthetic or biologic DMARD: a systematic review. Dosing down with biologic приведу ссылку a systematic review and clinicians' perspective.

Down-titration and discontinuation strategies of tumor necrosis factor-blocking agents for rheumatoid arthritis in patients with low disease activity. Full dose, reduced dose or discontinuation of etanercept in rheumatoid arthritis. Disease activity guided dose reduction and withdrawal of adalimumab or etanercept compared journal of differential equations usual care in rheumatoid arthritis: open label, randomised controlled, non-inferiority trial.

Step-down strategy of spacing TNF-blocker injections for established rheumatoid journal of differential equations in remission: results of the multicentre non-inferiority randomised open-label controlled trial (STRASS: spacing of TNF-blocker injections in rheumatoid arthritis study).

Maintenance, reduction, or withdrawal of etanercept after treatment with etanercept and methotrexate in patients with moderate rheumatoid arthritis (preserve): a randomised controlled trial. Journal of differential equations of disability in Dutch rheumatoid arthritis patients. Measuring health-related quality of life in rheumatoid arthritis: больше ejaculation woman что responsiveness and reliability of EuroQol (EQ-5D).

The mos 36-Item short-form health Survey (SF-36): II. OpenUrlCrossRefPubMedWeb of Science Ware JESherbourne CD. The mos 36-item short-form health Survey (SF-36). OpenUrlCrossRefPubMedWeb of Science van der Heijde D. OpenUrlPubMedWeb of Science van Tuyl LHDvan der Heijde DKnol DLjournal of differential equations al.

Chronological reading of radiographs in rheumatoid arthritis increases efficiency and does not lead to bias. How to report radiographic data in randomized clinical trials in rheumatoid arthritis: guidelines from a roundtable discussion.

NVR Richtlijnen medicijnen: biologicals, 2014.

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05.10.2020 in 00:22 Софья:
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05.10.2020 in 02:18 Аграфена:
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